生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析

目的 评价生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形（arteriovenous malformations,AVMs）的临床疗效。方法 13例颌面部软组织AVMs患者,男8例,女5例,平均年龄28.2岁。在超选择性血管内栓塞基础上,通过经皮注射生物胶联合OK-432及博莱霉素3~5次进行硬化治疗。结果 除术区1周内肿胀外,均无严重并发症出现。随访14~58个月（平均27.4个月）,3例治愈,8例显效,2例有效,无无效病例。结论 生物胶联合OK-432及博莱霉素经皮硬化治疗术治疗颌面部软组织AVMs效果良好,方法简单、安全、可靠。

Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients

PURPOSE: To evaluate the clinical curative effect of percutaneous sclerotherapy of arteriovenous malformations (AVMs) of soft tissues of the maxillofacial region using fibrin glue combined with OK-432 and bleomycin. METHODS: Thirteen patients with AVMs of the maxillofacial region (8 males and 5 females; mean age: 28.2 years, range: 16-46 years) were treated with a percutaneous injection of fibrin glue combined with OK-432 and bleomycin for 3-5 times following super-selective intra-arterial embolization (SIAE). RESULTS: All patients had significant swelling postoperatively for up to 1 week without major complications. The follow-up period ranged from 14-58 months (mean: 27.4 months). Three lesions were completely involuted, eight lesions were mostly involuted, and other two lesions were partially involuted. None of the lesions showed minimal involution or non-involution. CONCLUSIONS: Percutaneous sclerotherapy using fibrin glue combined with OK-432 and bleomycin following SIAE provides a simple, safe, and reliable alternative treatment for AVMs of soft tissues of maxillofacial region.