不同血清钙水平对终末期肾脏病患者血管钙化及心血管原因死亡的影响

Correlation between serum calcium and the vascular calcification and cardiovascular mortality in patients with end-stage renal disease

Objective: To investigate the correlation between serum calcium and the vascular calcification and cardiovascular mortality in patients with end-stage renal disease (ESRD). Methods: Clinical data of 160 cases of ESRD patients with regular hemodialysis were included. All cases were divided into three groups based on the serum calcium level: lower than normal (2.0 mmol/L＜Ca＜2.25 mmol/L), normal(2.25 mmol/L≤Ca≤2.75 mmol/L), higher than normal (Ca ＞2.75 mmol/L). All the clinical data including age, gender, serum calcium, vascular calcification rate and cardiac event occurrence rate were recorded. The vascular calcification was measured using X-rays. And the cardiac event occurrence rates in two years of all cases with different serum calcium levels were recorded. Kaplan-Meier methods were used to compute the survival rate. Results: There were 147 patients enrolled in the study at last, with a mean age of (57.76±13.43) years old, and 72 of them were male (48.9%). The degree of vascular calcification and serum calcium levels were positively correlated. The occurrences of cardiovascular event for the three groups had significance differences (P＜0.05）. The cardiovascular mortalities in 24 months for the three groups had significance differences（P=0.012）. Conclusion: The level of serum calcium may influence the vascular calcification and cardiovascular mortality in end-stage renal disease patients to some degree.