慢性乙型病毒性肝炎肝硬化发生肝细胞癌的危险因素分析

?目的: 探讨慢性乙型病毒性肝炎肝硬化发生肝细胞癌（HCC）的危险因素。方法: 研究对象为317例慢性乙肝患者，包括183例慢乙肝肝硬化患者（肝硬化组）和134例慢乙肝相关HCC患者（HCC组），对其性别、年龄、吸烟及饮酒习惯、伴发疾病、实验室检查指标等资料进行比较，探讨慢乙肝肝硬化发生HCC的危险因素。结果: HCC组患者男性所占比例、年龄、有长期大量饮酒习惯、血HBV DNA阳性、合并糖尿病（DM）及高血压所占比例均高于肝硬化组，两组比较P均<0.05。Logistic回归分析显示，男性、年龄较大、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素（OR分别为0.326、1.055、2.988、2.031，P均<0.05）。结论: 男性、年龄升高、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素。

Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis

?Objective: To investigate the risk factors of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related liver cirrhosis. Methods: A total of 317 patients with chronic hepatitis B were selected and divided into two groups: cirrhosis group with 183 patients and HCC group with 134 group. A case control study was conducted and the two groups were compared in terms of gender, age, smoking and drinking habits, accompanied disease and laboratory test results to explore the risk factors of HCC in patients with HBV-related liver cirrhosis. Results: The mean age, the proportions of men, drinking habits, HBV DNA positive and diabetes mellitus (DM) in HCC group were significantly higher than cirrhosis group, P<0.05. Logistic regression showed that sex, age, HBV DNA positive and DM were independent risk factors for HCC in patients with HBV-related liver cirrhosis (OR=0.326, OR=1.055, OR=2.988, OR=2.031, respectively, all P<0.05). Conclusions: Sex, older age, HBV DNA positive and DM are independent risk factors for HCC in patients with HBV-related liver cirrhosis.