Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats |
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Authors: | Haiyu Guo Young-Hwan Ban Yeseul Cha Tae-Su Kim Sung-Pyo Lee Eun Suk An Jieun Choi Da Woom Seo Jung-Min Yon Ehn-Kyoung Choi Yun-Bae Kim |
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Institution: | 1.Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea2.Anydoctor Healthcare Co., Ltd., Cheonan, Chungnam, Republic of Korea |
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Abstract: | Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases, the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated. SpragueDawley rats were fed a diet containing the oils or trans-fat, and then body weights, blood lipids, and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion (MCAO) were analyzed. All the oils and trans-fat, except perilla oil, significantly increased body fats and body weight gain. Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides, respectively, while perilla oil decreased both cholesterols and triglycerides. Perilla oil not only attenuated cerebral infarction, but also restored locomotor activity and rota-rod performances of MCAO rats. It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke. |
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Keywords: | plant oil trans-fat blood lipid body fat ischemic stroke physical activity |
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