马来酸噻吗洛尔和普萘洛尔治疗婴幼儿表浅型血管瘤的疗效分析

目的 比较外用马来酸噻吗洛尔与口服普萘洛尔治疗婴幼儿表浅型血管瘤的疗效。方法 回顾分析中国医科大学附属口腔医院口腔颌面外科门诊收治的50例表浅型血管瘤患儿, 27例外用0.5%马来酸噻吗洛尔滴眼液,为A组;23例采用口服普萘洛尔治疗,为B组。随访12个月,每个月定期复诊。采用SPSS18.0软件包对数据进行秩和检验,比较2组治疗效果、显效时间及不良反应的差异。结果 随访12个月,A组显效率为63.0%, B组显效率为65.2%,2组治疗效果及显效时间无显著差异（P>0.05）;A组不良反应显著少于B组（P<0.05）,2组均未出现危及患儿生命的严重不良反应。结论 采用外用马来酸噻吗洛尔治疗婴幼儿表浅型血管瘤安全有效。与口服用药相比, 本方法效果显著且不良反应少,可推荐为一线用药方案。

Evaluation of the efficacy and safety of 0.5% timolol maleate solution or oral propranolol in the treatment of superficial infantile hemangiomas

PURPOSE: To investigate the clinical effects of 0.5% timolol maleate solution or oral propranolol in treating superficial infantile hemangiomas. METHODS: A total of 50 patients with superficial infantile hemangiomas were retrospectively analyzed, 27 cases received topical 0.5% timolol maleate solution alone (group A), and 23 cases received oral propranolol alone (group B). Patients were followed up for 12 months. SPSS18.0 software package was used to compare the difference of therapeutic efficacy, the response time and adverse reactions between group A and group B. RESULTS: The effectiveness of group A and group B was 63.0%and 65.2%, respectively. The therapeutic efficacy and response time after 12 months had no significant difference between group A and B (P>0.05). Compared with group B, group A had fewer adverse reactions（P<0.05）. No serious adverse effects were encountered in both groups. CONCLUSIONS: Topical 0.5% timolol maleate solution is effective and safe in the treatment of superficial infantile hemangiomas. It could be considered as the first-line treatment especially for superficial infantile hemangiomas.