复发性阿弗他溃疡患者焦虑与唾液皮质醇和脱氢表雄酮水平的相关性研究

目的:探讨复发性阿弗他溃疡(RAU)患者焦虑与唾液皮质醇水平、唾液脱氢表雄酮(DHEA)水平及其比值的相关性。方法:上午8~10点之间收集唾液样本,并采用医院焦虑抑郁量表焦虑分表(HAD-A)评估RAU实验组(30例)和对照组(30例)的焦虑状态,采用酶联免疫吸附法测定受试者唾液中皮质醇及 DHEA的水平,并计算二者间的比值。结果:RAU实验组的焦虑得分、唾液皮质醇水平及唾液皮质醇/DHEA比值均明显高于对照组(P<0.05);唾液DHEA水平虽低于对照组,但差异无统计学意义。RAU组唾液皮质醇水平及唾液皮质醇/DHEA的比值与焦虑得分呈正相关(r=0.685,r=0.641,P<0.01),而唾液DHEA水平与焦虑得分呈负相关(r=-0.494, P<0.01)。结论:焦虑与RAU的发病有关。因此,对于RAU患者除了传统的治疗方法外,适当的心理支持疗法也是必要的。

Association between Anxiety and Salivary Cortisol as well as DHEA Levels in Patients with RAU.

Objective: To discuss the correlation among degrees of anxiety and the salivary levels of cortisol, levels of dehydroepiandrosterone (DHEA) and cortisol/DHEA ratio in patients with recurrent aphthous ulcer (RAU). Methods: Samples of saliva between 8.00 am and 11.00 am were collected. Anxiety levels of 30 RAU patients and 30 control patients were respectively evaluated by the Hospital Anxiety and Depression Scale for Anxiety (HAD-A). The method of ELISA was used to detect the levels of salivary cortisol and DHEA and to count their ratio. Results: The scores of anxiety and the level of salivary cortisol and cortisol/DHEA ratio of RAU group were significantly higher than those of controls (P<0.05). The salivary DHEA level of RAU was lower than that of controls, but there was no significant difference between two groups. The level of salivary cortisol and cortisol/DHEA ratio in patients with RAU were positively correlated with the anxiety Scores (r=0.685, r=0.641, P<0.01). The level of salivary DHEA was negatively correlated with the anxiety scores (r=-0.494, P<0.01). Conclusion: The anxiety involved in the pathogenesis of RAU. It is necessary to use some proper phychological supporting treatment for RAU patients except traditional treatment.