伏立康唑临床应用个体差异影响因素的文献分析

通过文献调研，就近年来影响伏立康唑个体差异相关因素的研究报道进行分析总结。探讨伏立康唑临床应用个体差异影响因素，为临床安全合理用药提供参考。伏立康唑个体差异受多种因素综合影响，其中CYP2C19单核苷酸多态性以及药物间相互作用是重要影响因素。应积极对伏立康唑临床应用开展相关药学监护，逐步通过构建血药浓度监测结合相关代谢基因多态性检测手段，建立个体化用药模型，实现精准化药物治疗的目的。

Influence factors of individual differences in clinical application of voriconazole

Through comprehensive literature research, recent advances of voriconazole were collected and reviewed. To summarize influence factors of individual difference in voriconazole, and provide a reference for rational clinical application. Individual differences in voriconazole were influenced by many factors. Genetic polymorphism especially CYP2C19 single nucleotide polymorphism and drug interaction played important roles. Pharmaceutical care for patients using voriconazole should be implemented. Therapeutic drug monitoring combined with genetic polymorphism detection should be gradually developed to realize individualized medication.