INCREASED LEVELS OF OSTEOCALCIN (SERUM BONE GLA-PROTEIN) IN RHEUMATOID ARTHRITIS |
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| Authors: | GEVERS, G. DEVOS, P. DE ROO, M. DEQUEKER, J. |
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| Affiliation: | 1Arthritis and Metabolic Bone Disease Research Unit, Division of Rheumatology, Department of Internal Medicine B-304I Pellenberg, Belgium
2Department of Nuclear Medicine, Catholic University of Leuven, University Hospital Pellenberg B-3041 Pellenberg, Belgium |
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| Abstract: | Serum osteocalcin was measured by radio-immunoassay in 56 patientswith rheumatoid arthritis (RA), and in 50 controls. Mean serum osteocalcin levels were significantly higher in patientswith RA. There was a positive correlation between osteocalcinand fasting mucopolysaccharide/creatinine ratio in both sexes,and between osteocalcin and fasting hydroxyproline/creatinineratio in women. Serum alkaline phosphatase activity, a lessspecific marker for bone formation, was also increased in RA,and there was a positive correlation with osteocalcin in bothsexes. These data suggest that overall bone turnover is increased inRA and that serum osteocalcin may provide additional informationfor the evaluation of bone metabolism in this disease. KEY WORDS: Bone, Osteocalcin, Rheumatoid arthritis |
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