Modulation of gamma-aminobutyric acid responses in the rat optic nerve |
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Authors: | Empson R M Sheardown M J Newberry N R |
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Affiliation: | Cerebrus Ltd, Oakdene Court, 613 Reading Road, Winnersh, Berkshire, RG41 5UA, Wokingham, UK. r.empson@rhbnc.ac.uk |
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Abstract: | Depolarising GABA(A) receptor-mediated responses recorded from the optic nerve using a grease gap technique were modulated by classical potentiators of GABA(A) receptors. The benzodiazepine, chlordiazepoxide, the barbiturate, pentobarbitone and the widely used anaesthetic, propofol, all potentiated gamma-aminobutyric acid (GABA) responses. They did so with different maximal efficacies, propofol>pentobarbitone>chlordiazepoxide, and potencies on the basis of EC(50) estimates, chlordiazepoxide>propofol>pentobarbitone. The greater than expected GABA potentiating properties of propofol were explained by a direct hyperpolarising action that occurred in the same concentration range as its action at the GABA(A) receptor but that was unlikely to be mediated by GABA(A) receptors. |
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