大鼠坐骨神经局部缺血后其神经元胞体超微结构的病理变化

采用结扎大鼠一侧髂总动脉致该侧坐骨神经局部缺血的方法，研究了其相关神经元胞体超微结构的病理变化。结扎髂总动脉的实验动物分别存活４，８，１０，１４天后，经升主动脉灌流杀死，取出腰髓第５节段和第５腰脊神经节，透射电镜下观察了腰髓前角细胞和仍神经节细胞超微结构的变化。

PATHOLOGICAL CHANGES IN THE ULTRASTRUCTURE OF NEURONAL SOMA AFTER SCIATIC NERVE ISCHEMIA IN RAT

Pathological changes in the infrastructure of neuronal soma were investigated by the method of ligaring one side common iliac artery of rats leading to sciatic nerve ischemia. After the common iliac artery was Hgated , the rats survived for 4,8,10,14 days respectivly, then were killed by perfusing through asending aorta. The specimens were obtained from the fifth lumbar segment of the spinal cord arid the fifth lumbar dorsal root ganglion, and observed under the transmission microscope. It was found that from 10~14 days after ischemia, both the anterior horn neurons and the dorsal root ganglion neurons produced retrograde degeneration, i. e. , the swelling of mitochondria, the dilation of Golgi complex, and the degranulation of rough endoplasmic reticulum. The study also indicated that the ischemia of the peripheral nerve led to retrograde degeneration.