Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions |
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Authors: | Chen A I McAdam A J Buhlmann J E Scott S Lupher M L Greenfield E A Baum P R Fanslow W C Calderhead D M Freeman G J Sharpe A H |
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Institution: | Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. |
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Abstract: | The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions. |
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