双膦酸盐类药物不良反应及应用评价

目的：双膦酸盐类（Diphosphonate）药物是近年发展起来的一类抗代谢性骨病新药,主要用于骨质疏松症、恶性肿瘤骨转移及高钙血症等。虽然此类药物产生的不良反应大部分是较轻微的,且是暂时性的。但随着其应用的日益广泛,该类药物对胃肠道、眼部、颚骨坏死、肌肉骨骼疼痛及肾脏等一些严重不良反应已引起人们的关注。本文对其不良反应与应用进行阐述和评价。方法：采用国内外文献检索方法。结果及结论：在临床上预防双膦酸盐类药物的不良反应,使患者更好地配合治疗,以达到最佳疗效。

ADRs Induced by Diphosphonate and Notice in the Application of Diphosphonate

OBJECTIVE：Diphosphonate, a newly developed drug for treating metabolic bone diseases such osteoporosis, malignant tumor osseous metastasis, hypercalcemia and so on. Most of the side effects of this agent are mild and temporary; however, with the increasingly widespread use of this agent, the serious adverse reactions （ADRs）occurred in organs such as gastrointestinal tract, ocular region, mandible （osteonecrosis of jawbone）, skeletal musculature （myosalgia and ostalgia）, kidney and so on have gained great attention in the clinic. This paper reviewed pertinent literature about the ADRs of diphosphonate to provide reference for clinical rational use of this drug. To describe the adverse drug reaction and to eveluate the use of diphosphonate. METHODS：To collecte medical literatures in recent years at home and abroad. RESULTS ＆ CONCLUSION： To ensure maximal therapeutic effects, the ADRs of diphosphonate should be preevented in clinic.