Enhancement of virulence of two environmental strains of Vibrio vulnificus after passage through mice |
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| Authors: | C A Kaysner M M Wekell C Abeyta |
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| Affiliation: | Seafood Products Research Center, Food and Drug Administration, Bothell, Washington 98041-3012. |
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| Abstract: | The virulence of two environmental strains of Vibrio vulnificus to iron-loaded adult mice was enhanced by passage through mice. Estimates of 50% lethal dose values (LD50) determined by end point titration were reduced 100- and 1000-fold for the two strains. Passage through mice also selected for the opaque colony type phase variation of V. vulnificus, reported by others to be more virulent to mice than a translucent colony type. |
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