急性心肌梗死患者血清脑钠肽水平与梗死后左室重构及心功能关系的探讨

目的探讨急性心肌梗死(AMI)患者血清脑钠肽(BNP)水平与梗死后左室重构(LVR)及心功能的关系。方法测定21例AMI患者血清BNP水平并同时行超声心动图检查测量左室舒张末期、收缩末期内径(LVDd、LVDs)、左室舒张末期、收缩末期容积(LVEDV、LVESV)及左室射血分数(LVEF)。结果21例AMI患者血清BNP水平显著升高,在LVR升高更为显著(P<0.01)且BNP水平与LVDd、LVEDV、LVESV显著呈正相关(r=0.44,0.48,0.62;P<0.05,0.05,0.01)与LVEF呈负相关(r=-0.64,P<0.01)。结论BNP可作为AMI早期诊断和发现LVR及心功能减低的一种简单易行的标志物。

Relationship plasma brain natriuretic peptide with left ventricular remodling and heart function in myocardial infarction

Objective To investigate the relationship plasma brain natriuretic peptide(BNP)level and left ventricular remodling(LVR) and ejection fraction(EF) after acute myocardial infarction.Methods BNP was determined in 21 acute myocardial infarction.Left ventricular diastolic diameter(LVDd) and.Left ventricular systolic diameter(LVDs) was measured in echocardiography and calculated left ventricular end diastolic volume(LVEDV) and left ventricular end systolic volume(LVESV)and EF.Results BNP was significantly high in 21 myocardial infarction and more significantly higher in LVR group(P<0.01).BNP was positive relation with LVDd and LVEDV and LVESV(r=0.44,0.48,(0.62;)P<0.05,0.05,0.01)and negative relation with EF(r=-0.64,P<0.01).Conclusion BNP can be a simple and available sign in diaganosis and finding LVR.