| 丙型肝炎的超微病理学研究 |
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| 引用本文： | 周晓军,张泰和,J.C.E.Underwood. 丙型肝炎的超微病理学研究[J]. 医学研究生学报, 1993, 0(2) |
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| 作者姓名： | 周晓军 张泰和 J.C.E.Underwood |
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| 作者单位： | 金陵医院超微病理科，金陵医院超微病理科，英国Shefficid大学医学院病理系 |
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| 摘 要： | 本研究对36例输血后慢性丙型肝炎进行了电镜观察,旨在确定人类丙型肝炎的超微结构特点。所有病例都经各项血清学检查(包括HCV抗体及HCV-RNA的检测)及组织学检查证实。各病例虽均未观察到以往人们在实验性丙型肝炎中报道的那些特殊结构,但在肝细胞及其问质中的确可以出现某些超微结构变化。多数病例(尤其是慢迁肝病例)中可见滑面内质网显著增生;粗面内质网扩张,网池中充满低电子密度絮状物质,偶而形成卷曲的膜性结构;窦周及肝细胞间隙胶原纤维增多;肝窦淋巴细细胞及枯否细胞增多;并常侵入肝细胞间;末见邻近肝细胞明显损伤。
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| 关 键 词： | 丙型肝炎 超微结构 内质网 |
The ultrastructural changes in human hepatitis C |
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| Zhou Xiaojun. The ultrastructural changes in human hepatitis C[J]. Bulletin of Medical Postgraduate, 1993, 0(2) |
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| Authors: | Zhou Xiaojun |
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| Affiliation: | Department of Ultrastructural Pathology |
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| Abstract: | Electron microscopy of 36 liver specimens from posttransfussion chronic hep- atitis C was carried out to determine the ultrastructural features in human hepatitis C. All the cases were confirmed by histological examination and serological tests in- cluding anti-HCV antibodies.No identical ultrastructural changes with those de- scribed in experimentally induced hepatitis C was detected,though some ultrastruc- tural alterations,not pathognomomic,did occur in hepatocellular cytoplasm.Promi- nent proliferation of smooth endoplasmic reticulum was frequently found,notably in cases with chronic persistent hepatitis,and rough endoplasmic reticulum showed distended cisternae filled with light fluffy material,occasionally forming curved membraned structure in the cisternae.Intercellular and perisinusoidal fibrosis,and invasion of lymphocytes into Disse and intercellular spaces in the absence of con- comitant liver cell injury in the immediate vicinity were ofter noted in the study. |
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| Keywords: | hepatitis C ultrastrueture endoplasmic retieulum |
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