时辰化疗联合放疗治疗晚期食管癌

目的探讨时辰化疗联合放疗治疗晚期食管癌的疗效。方法晚期食管癌患者80例，随机分为单纯放疗组（单放组）和时辰化疗联合放疗组（综合组），两组各40例。时辰化疗方法：顺铂（DDP）联合5-氟尿嘧啶（5-Fu）静脉滴注，DDP20mg／m^2，每日10时至22时给药，5-Fu 500mg／m^2，每日22时至次日10时给药，5d为1个疗程，第29天重复。放疗：综合组肿瘤剂量56～60Gy，照射5～6周；单放组肿瘤剂量64—70Gy，照射6～7周，观察患者治疗的效果及影像改善情况，随访6～20个月。结果综合组和单放组总有效率分别为92．5％（37／40）及75．0％（30／40），两组差异有统计学意义（P〈0．05）；综合组和单放组患者1年生存率分别为75．0％（30／40）和52．5％（21／40），差异有统计学意义（P〈0．05）；2年生存率分别为47．5％（19／40）和30．0％（12／40），差异有统计学意义（P〉0．05）。结论时辰化疗联合放疗是一种治疗晚期食管癌的有效方法。

Chrono-chemotherapy with radiotherapy in treatment of advanced esophageal carcinoma

Objective To investigate the treatment effects of chrono-chemotherapy (CC) with radiotherapy on advanced esophageal carcinoma. Methods Eighty patients with advanced esophageal carcinoma were randomly divided into two groups: a radiotherapy group (R) and a chrono-chemotherapy plus radiotherapy group (CC+R). 40 patients received radical radiotherapy alone and the radiation dose was 64-70 Gy for 6-7 weeks (R). 40 patients were treated by chrono--chemotherapy plus radiotherapy. Patients were chrono-introvein infusion with cisplatin and 5-fluorouraeil. Patients were given cisplatin 20 mg/m2 infusion on 10-hour-22-hour and 5-fluorouracil 500 mg/m2 by infusion from 22:00 to 10:00 next day. The period of treatment was 5 days. Treatment was repeated on the 29th day. The radiation dose was 50-60 Gy, for 5-6 weeks (CC+R). The treatment effects and X images of all patients were observed and followed up for 6 to 20 months. Results The improvements of clinical symptoms were 92.5% (37/40) in CC+R group and 75.0% (30/40) in R group, with an obvious difference between the two groups (P <0.05). The 1-, 2-year survival rates were 75.0% (30/40) and 52.5% (21/40), 47.5% (19/40) and 30.0% (12/40) in two groups, with significant difference in 1-year survival rate between the two groups (P <0.05). Conclusion Radiotherapy combined with chrono-chemotherapy was an effective method for advanced esophageal carcinoma.