90例冠心病患者N末端脑钠肽原检测临床研究

目的探讨冠心病患者检测N末端脑钠肽原(NT-proBNP)的临床意义。方法选取稳定型心绞痛(SAP)患者25例,不稳定型心绞痛(UAP)患者45例,急性心肌梗死(AMI)患者20例,对照组健康体检者25例。采用快速免疫荧光法(RAMP)分别测定其NT-proBNP数值。结果对照组(40.2±76.3)ng/L,SAP组(73.6±98.6)ng/L,UAP组(298.3±367.9)ng/L,AMI组(1295.6±1841.2)ng/L,SAP组和对照组NT-proBNP浓度差异无统计学意义(P0.05),AMI组高于UAP组(P0.05),UAP组NT-proBNP浓度明显高于SAP组(P0.05)。结论 NT-proBNP水平与冠心病临床严重程度、心肌缺血严重程度相关,可能是冠心病临床严重程度、心肌缺血严重程度的一个较好的预测指标。

Detection of N-Terminal Pro-BNP in Coronary Heart Disease:A Clinical Study of 90 Cases

Objective To explore the clinical significance of NT-proBNP detection. Methods We selected 25 cases of stable angina pectoris as SAP group,45 cases of unstable angina pectoris as UAP group,20 cases of acute myocardial infarction as AMI group and 25 healthy people as control group. The NT-proBNP level was detected by using a rapid immunofluorescence technique （RAMP）. Results Control group： （40.2 ±76.3）ng/L,SAP group： （73.6 ±98.6）ng/L,UAP group： （298.3 ±367.9）ng/L,AMI group： （1295.6 ±1841.2）ng/L. There was no significant difference in the NT-proBNP level between the SAP group and the control group （P〉0.05）.However,there was a significant difference in the NT-proBNP level between the AMI group and the SAP group （P〈0.05）,and the NT-proBNP level of the UAP group was obviously higher than that of the SAP group （P〈0.05）. Conclusion The NT-proBNP level is correlated with the clinical severity of coronary heart disease and myocardial isehemia, and may become a good predictor for coronary heart disease and its clinical severity.