糖尿病患者高血压与趋钙激素关系的初步探讨

目的：探讨趋钙激素对糖尿病（ＤＭ）合并高血压患者发病的影响。方法：对象为４０例ＤＭ患者，其中非高血压（ＤＭ１组）２１例、合并高血压（ＤＭ２组）１９例及１５例健康对照者。对３组进行血清钙、磷、甲状旁激素（ＰＴＨ）、降钙素（ＣＴ）、葡萄糖耐量试验（ＯＧＴＴ）及胰岛素（ＩＮＳ）和Ｃ－肽（Ｃ－Ｐ）测定，并计算ＰＴＨ／ＣＴ比值和葡萄糖／胰岛素指数。结果：３组检测结果比较显示ＤＭ２组血清钙降低、ＰＴＨ升高、Ｃ

Preliminary Study on the Relationship Between Hypertension and Calcitropic Hormones in Diabetic Patients

Objective: To evaluate the effect of calcitropic hormone in patients with diabetes mellitus complicated with hyperten-sion. Methods:Serum calcium and phosphorus,parathyroid hormone (PTH) ,calcitonin (CT) ,OGTT,insulin (INS) ,and C-peptide (C-P) were measured in 15 healthy persons (control group) and 40 diabetic patients which included 21 non-hyper-tensives (group 1) and 19 hypertensives (group 2). The ratio of PTH/CT and the index of glucose/insulin were calculated. Results:The levels of serum calcium,CT,and the index of glucose/insulin in group 2 significantly decreased compared with the other two groups (P < 0.01), and the levels of PTH, insulin at OGTT 2 hours, and the ratio of PTH/CT in group 2 sig-nificantly increased compared with the other two groups (P<0.01). There was a positive correlation between mean arterial pressure (MAP) and the level of serum PTH,and PTH/CT analyzed by single factor correlation. The ratio of PTH/CT is a main factor in the onset of hypertension in diabetic patients analyzed by multiple progressive regression. Conclusion: The study of the levels of serum PTH,CT,and the ratio of PTH/CT has an important value in pathogenesis of hypertension in diabetic patients.