Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women |
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Authors: | van der Steeg Jan Willem Steures Pieternel Eijkemans Marinus J C Habbema J Dik F Hompes Peter G A Burggraaff Jan M Oosterhuis G Jur E Bossuyt Patrick M M van der Veen Fulco Mol Ben W J |
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Affiliation: | Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, The Netherlands. j.w.vandersteeg@amc.uva.nl |
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Abstract: | BACKGROUND: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. CONCLUSIONS: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women. |
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Keywords: | obesity/subfertility/pregnancy chance/spontaneous conception |
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