转化生长因子β3在病毒性肝炎肝组织中的表达及其意义

目的为了解转化生长因子β３（ＴＧＦ－β３）在病毒性肝炎肝组织中的表达及其与肝纤维化的关系。方法对３３例病毒性肝炎病人肝组织进行了ＴＧＦ－β３免疫组化研究。结果ＴＧＦ－β３主要分布在血窦壁及窦内细胞、坏死灶、汇管区、纤维间隔、假小叶中的肝细胞以及重型肝炎坏死区的肝细胞。其阳性表达的强度为肝硬变慢性重型肝炎＞慢性肝炎重度＞中度＞轻度＞急性肝炎；与肝功能损害的关系表明，随着ＴＧＦ－β３在肝组织中表达的增高，血清总胆红质升高明显，而凝血酶原时间活动度明显下降。结论ＴＧＦ－β３在肝组织中的表达与病毒性肝类肝纤维化及肝硬变、重型肝炎的发生发展及预后有密切关系。

Study on expression of transforming growth factor-beta 3 in the liver tissues]

33 specimens of liver biopsy from patients with different types of viral hepatitis were detected for transforming growth factor-beta 3(TGF-beta 3) by immunohistochemistry. The results showed that TGF-beta 3 mainly distributed in the sinusal walls cells in sinus portal, areas fibrous, septum, hepatocytes in pseudolobes and necrotic areas of severe hepatitis. The expressing intensity of TGF-beta 3, was stronger in the cirrhosis, chronic severe hepatitis than that in the chronic and acute hepatitis. As the expression of TGF-beta 3 increased, the level of serum bilirubin ascended and plasmozyme activity was prolonged. It may be concluded that the expression of TGF-beta 3 is correlated with severe hepatitis and the progress of the liver cirrhosis.