咖啡酸、阿魏酸对醋酸去氧皮质酮—盐高血压大鼠内皮素—1作用的研究

用咖啡酸、阿魏酸对ＤＯＣＡ盐高血压大鼠内皮素１ 作用的进行了研究。结果表明：（１） 咖啡酸与阿魏酸能使得ＤＯＣＡ盐高血压大鼠的血压明显降低，与未加处置的阳性对照组相比，收缩压值的降低有明显差异；（２） 咖啡酸与阿魏酸能明显抑制ＤＯＣＡ盐高血压大鼠主动脉血管和心脏的组织增生；（３） 咖啡酸与阿魏酸能降低ＤＯＣＡ盐高血压大鼠血浆ＥＴ１ 浓度，与阳性对照组相比，除咖啡酸１００ｍｇ／ｋｇ 剂量组外，其余剂量组血浆ＥＴ１ 浓度的降低有显著性意义；（４） 三个剂量组的咖啡酸、阿魏酸可使得ＤＯＣＡ盐高血压大鼠的心脏、肾脏和主动脉血管ＥＴ１ｍ ＲＮＡ 的表达增加；（５） 三个剂量组的咖啡酸、阿魏酸均能抑制ＤＯＣＡ盐高血压大鼠心脏、肾脏和胸主动脉血管ｃｆｏｓ、热休克蛋白７０（ＨＳＰ７０） 基因的表达。本研究结果提示：咖啡酸与阿魏酸能通过对ＥＴ１ 的作用而产生对ＤＯＣＡ盐高血压大鼠降压、血管和心脏组织增生、原癌基因表达等生物效应。

The Effects of Caffeic Acid and Ferulic Acid on ET 1 of DOCA salt Hypertensive Rats

The effects of caffeic acid and ferulic acid on endothelin 1 were conducted through DOCA salt hypertensive rats. The results showed that:(1)caffeic acid and ferulic acid could decrease the systolic blood pressure of DOCA salt hypertensive rats significantly comparing with non treated DOCA salt hypertensive rats;(2) caffeic acid and ferulic acid could blunt the tissue proliferation of aorta and heart of DOCA salt hypertensive rats;(3)caffeic acid and ferulic acid decreased the ET 1 concentrations of DOCA hypertensive rats markedly comparing with control group except 100 mg/kg of caffeic acid;(4) caffeic acid and ferulic acid increased the expression of mRNA ET 1 on aorta, heart and kidney;(5)the gene expression of c fos and hot shock protein 70 mRNA of aorta , heart and kidney were inhibited by caffeic acid and ferulic acid. These results suggested the caffeic acid and ferulic acid affect the ET 1 of DOCA salt hypertensive rat and induce the effects of blunted blood pressure evaluation, inhibition of cardiovascular proliferation and oncogene gene expression.