| ELECTRO-ACUPUNCTURE ANALGESIA AND ANALGESIC ACTION OF NAGA |
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| 作者姓名： | 潘小平 张炳海 王德岭 高慧 杜桂珍 陈伯英 郑莉芳 |
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| 作者单位： | Department of Acupuncture Analgesia Research and Department of Chemistry Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai，Department of Acupuncture Analgesia Research and Department of Chemistry，Shanghai First Medical College，Shanghai |
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| 摘 要： | Naga is one of the numerous opioid peptidespresented in the central nervous system.It is atetrapeptide having potent analgesic action of longduration.The pain-inhibiting action of Naga is me-diated by opiate receptor.Naga acts by injection not only into the nu-cleus or ventricle but also into the vein,suggestingthat the drug can resist enzyme degradation andpenetrate the blood-brain-CSF barrier.Analgesic action of Naga is correlated to dosage.Large dose may prolong the opiate agonist activity.Brain Naga content was increased markedlyafter acupuncture and gradually returned to normallevel when stimulation was stopped.Naga is relat-ed to acupuncture analgesia.Synergitic action between Naga,Leu-EK andβ-EP was described.Rise in Naga concentration mayinduce the release of Leu-EK or β-EP,and electro-acupuncture may promote this action.
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