| PCR技术在产前诊断胎儿非整倍体的应用 |
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| 引用本文： | 刘静,张颖,岳天孚. PCR技术在产前诊断胎儿非整倍体的应用[J]. 国外医学:妇产科学分册, 2010, 0(1): 5-8 |
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| 作者姓名： | 刘静 张颖 岳天孚 |
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| 作者单位： | 天津医科大学总医院妇产科,300052 |
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| 摘 要： | 大多数染色体异常为21,13,18号染色体及性染色体的非整倍体异常,血清筛查结果为高风险及年龄35岁以上的妊娠妇女均需进行产前诊断。而产前诊断染色体异常的传统方法是核型分析,染色体核型分析结果一般需要2～3周。随着分子生物学的飞速发展,聚合酶链反应技术不断应用于染色体非整倍体的产前诊断,这些新技术敏感性高、特异性强、操作简便、实验周期短,适合于非整倍体的产前诊断。
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| 关 键 词： | 聚合酶链反应技术 非整倍体 产前诊断 应用 |
The Application of PCR in the Prenatal Diagnosis of Fetal Aneuploidy |
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| LIU Jing,ZHANG Ying,YUE Tian-fu. The Application of PCR in the Prenatal Diagnosis of Fetal Aneuploidy[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2010, 0(1): 5-8 |
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| Authors: | LIU Jing ZHANG Ying YUE Tian-fu |
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| Affiliation: | LIU Jing,ZHANG Ying,YUE Tian-fu.Department of Obstetrics , Gynecology,Tianjin Medical University General Hospital,Tianjin 300052,China |
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| Abstract: | The chromosomal abnormalities are usually 21,13,18 chromosomes and the sex chromosome aneuploids.The results of serum screening is that the high-risk and the age over 35 pregnant women are required for prenatal diagnosis.Traditional karyotyping is considered the gold standard for invasive prenatal diagnosis,but the results take 2-3 weeks.With the rapid development of molecular biology,polymerase chain reaction used in aneuploidy of prenatal diagnosis.Polymerase chain reaction is high sensitivity and specifi... |
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| Keywords: | Polymerase chain reaction Aneuploidy Prenatal diagnosis Application |
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