| 尖锐湿疣患者血清白细胞介素18和干扰素γ水平的研究 |
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| 引用本文： | 刘国英,姚航平.尖锐湿疣患者血清白细胞介素18和干扰素γ水平的研究[J].浙江大学学报(医学版),2003,32(4):327-329. |
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| 作者姓名： | 刘国英 姚航平 |
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| 作者单位： | 浙江大学医学院附属第一医院,浙江,杭州,310003 |
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| 基金项目： | 浙江省自然科学基金资助项目 (399137) |
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| 摘 要： | 目的 :研究白细胞介素 18(IL- 18)和干扰素 γ(IFN- γ)在尖锐湿疣发病机理中的作用。方法 :采用酶联免疫吸附 (EL ISA)法 ,测定了 30例尖锐湿疣患者血清 IL- 18、IFN- γ含量。结果 :尖锐湿疣患者组的血清 IL- 18、IFN- γ水平显著高于正常人组 (IL- 18:132 .0 0± 5 2 .92 μg/ L vs5 0 .79± 2 3.4 8μg/ L,P<0 .0 1;IFN- γ:80 .83± 2 0 .4 6 μg/ Lvs2 0 .71± 11.18μg/ L,P<0 .0 1) ,且 IFN- γ水平增高与 IL- 18水平增高呈正相关 (r=0 .75 4,t=6 .0 81,P<0 .0 1)。结论 :在人类乳头瘤病毒感染时 ,机体的抗感染免疫有一定的激活 ,产生 IL- 18、IFN- γ等抗病毒因子 ,这可能与病毒最终被清除有一定关系。
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| 关 键 词： | 尖锐湿疣／病理生理 白细胞介素－18／血液 干扰素Ⅱ型／血液 乳头状瘤病毒 人 |
| 文章编号： | 1008-9292(2003)04-0327-03 |
| 修稿时间： | 2001年5月9日 |
Study of levels of IL-18 and IFN-γ in serum of patients with condyloma acuminatum |
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| LIU Guo-ying,YAO Hang-ping.Study of levels of IL-18 and IFN-γ in serum of patients with condyloma acuminatum[J].Journal of Zhejiang University(Medical Sciences),2003,32(4):327-329. |
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| Authors: | LIU Guo-ying YAO Hang-ping |
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| Institution: | The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. |
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| Abstract: | OBJECTIVE: To study the role of interleukin(IL)18 and interferon gamma (IFN-Gamma) in the pathogenesis of condyloma acuminatum(CA). METHODS: Double antibody sandwich ELISA was used to measure the levels of IL-18 and IFN-Gamma in serum of 30 cases of CA. RESULT: The serum levels of IL-18 and IFN-Gamma of the CA patients were significantly higher than those of normal controls IL-18 132.00 +/-52.92 microg/L compared with 50.79 +/- 23.48 microg/L, P<0.01 IFN-Gamma:80.83 +/-20.46 microg/L compared with 20.71 +/-11.18 microg/L P <0.01) and IL-18 levels were positively correlated with IFN-Gamma concentrations (r=0.754, t=6.081, P <0.01). CONCLUSION: These data suggest that during infection of human papilloma viruses, anti-infective immune responses are activated. |
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