| 改良FLAG方案治疗难治性急性髓细胞白血病的初步分析 |
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| 关 键 词： | FLAG方案 治疗 难治性急性髓细胞白血病 氟达拉宾 粒细胞集落刺激因子 阿糖胞苷 |
Modified FLAG regimen in the management of refractory acute myeloid leukemia] |
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| Long-jiang Yang,Fan-yi Meng,Bing Xu,Xiao-li Liu,Wei-yang Zheng,Yu Zhang,Fen Huang,Dan Xu,Jing Sun,Qi-fa Liu. Modified FLAG regimen in the management of refractory acute myeloid leukemia][J]. Journal of First Military Medical University, 2003, 23(10): 1054-1055 |
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| Authors: | Long-jiang Yang Fan-yi Meng Bing Xu Xiao-li Liu Wei-yang Zheng Yu Zhang Fen Huang Dan Xu Jing Sun Qi-fa Liu |
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| Affiliation: | Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. yanglongjiang@hotmail.com |
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| Abstract: | OBJECTIVE: To evaluate the therapeutic effect of modified FLAG regimen in the management of refractory acute myeloid leukemia (AML). METHODS: Sixteen patients with refractory AML were divided into two groups. In modified FLAG regimen group (n=10), the patients received fludarabine (Flu, 50 mg/d, VDx5 d) and Ara-c (200 mg/d, VDx5 or 7 d). The regimen for classic FLAG group (n=6) consisted of Flu (50 mg/d, VDx5d), Ara-C (500 or 1,000 mg/d, VDx5d) and G-CSF (300 microg/d, x5 d, subcutaneously injected 4-6 hours before chemotherapy). Each patient received subcutaneous G-CSF (300 microg/d) when the white blood cell count was lower than 1.0x10(9)/L till the condition was corrected. RESULTS: The total complete remission(CR) rate of the 16 patients was 50% (8/16). Seven patients in modified group achieved CR (70%) and only one of the classic group did (17%, P<0.05). Episodes of infections were lower in modified group than in the classic group (50% vs 83%). CONCLUSION: Modified FLAG regimen is more likely than classic FLAG regimen to achieve CR and reduce infections in patients with refractory AML. |
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