膀胱移行细胞癌中FHIT与MMP-2的表达及其临床意义

目的:探讨脆性组氨酸三联体(FHIT)和基质金属蛋白酶-2(MMP-2)在膀胱移行细胞癌(TCCB)组织中的表达及其与临床病理特征的关系。方法:免疫组化S-P法检测10例正常膀胱组织,50例膀胱癌组织中FHIT、MMP-2表达情况。结果:FHIT、MMP-2在正常膀胱组织和TCCB组织中的表达具有显著性差异(P<0.05)。FHIT、MMP-2在TCCB不同病理分级中的表达差异和MMP-2在TCCB不同临床分期中的表达有显著性差异(P<0.05)。FHIT、MMP-2表达存在负相关性(r=-0.362,P<0.05)。结论:联合检测FHIT、MMP-2在膀胱癌组织中的表达可为膀胱癌的早期诊断、进一步治疗及预后判断提供依据。

Expressions and clinical significance of FHIT and MMP - 2 in transitional cell carcinoma of bladder

Objective: To study the expressions of fragile histidine triad(FHIT) and matrix metalloporteinases 2(MMP-2) in transitional cell carcinoma of bladder(TCCB),and their relation with clinicopathological characters.Methods: Immunohistochemical staining S-P method was used to detect the expressions of FHIT and MMP-2 in 10 cases of normal bladder tissues,and 50 cases of TCCB tissues.Results: There were statistical significance between the expressions of FHIT and MMP-2 in normal group and carcinoma(P< 0.05).The positive expression of FHIT and MMP-2 was significantly increased with stage( P< 0.05),while the expression of MMP-2 was significant different with grade(P< 0.05).Negative correlation was found between the expressions of FHIT and MMP-2(r=-0.362,P=0.01).Conclusion: Detection of FHIT and MMP-2 may have potential effects on the early diagnosis,treatment and prediction of prognosis of TCCB.