无创双水平正压通气(BiPAP)联合应用冻干重组人脑利钠肽抢救呼吸重症疾病的临床意义

目的讨联用无创双水平正压通气(Bi PAP)与冻干重组人脑利钠肽(rh BNP)抢救呼吸重症疾病的临床应用价值。方法按就诊顺序编号将收治的54例呼吸重症疾病患者分为对照组和观察组各27例。对照组给予Bi PAP辅助呼吸,改善患者呼吸情况,同时给予常规治疗。观察组在对照组基础上加用rh BNP治疗,比较两组治疗后的动脉血氧分压、CO2分压、血p H值、意识恢复时间及脱机成功率和住院死亡率。结果观察组动脉血氧分压、CO2分压、血p H值均得到有效改善,观察组意识恢复时间为(3.2±0.7)d,对照组为(5.3±1.2)d,组间比较,差异具有统计学意义(P0.05)。观察组脱机时间短于对照组,住院病死率低于对照组,差异具有统计学意义(P0.05)。结论联用无创双水平正压通气(Bi PAP)与rh BNP是抢救呼吸重症疾病患者的有效方案,可改善临床症状,抢救成功率较高,值得临床借鉴和推广。

Clinical Significance of Noninvasive Bilevel Pressure Ventilation (Bi-PAP) Joint the Application of Lyophilized Recombinant Human Brain Natriuretic Peptide in Rescuing Breathing with Severe Disease

Objective To discuss the clinical significance of noninvasive bilevel pressure ventilation （Bi-PAP） joint the application of lyophilized recombinant human brain natriuretic peptide in rescuing breathing with severe disease. Methods According to visit order number, 54 patients with severe respi-ratory in our hospital from March 2012 to in March 2014 were divided into control group and observa-tion group, each group of 27 cases. The control group was given BiPAP assisted breathing to improve patients’breathing, and routine therapy. The observation group was given rhBNP treatment based on control group. After the treatment, arterial oxygen partial pressure, arterial partial pressure of CO2, blood pH value, the consciousness recovery time and the success rate and mortality of two groups of patients were compared. Results Arterial oxygen partial pressure, CO2 partial pressure, arterial blood pH values in observation group have been effectively improved, consciousness recovery time in observa-tion group was （3.2±0.7）d, and that in control group was （5.3±1.2）d, There was statistically significant difference between the two groups（P〈0.05）. Offline timein observation group was shorter than the control group, the fatality rate was lower than the control group, with significant difference（P〈0.05）. Conclusion Using noninvasive bilevel pressure ventilation （BiPAP） joint the application of lyophilized recombinant human brain natriuretic peptide is effective in rescuing breathing with severe disease, improved clinical symptoms, and high success rate of rescue, and it is worthy of reference and promotion.