应用聚合酶链反应技术检测乳腺肿瘤中EB病毒整合 |
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引用本文: | 张丽萍,许良中.应用聚合酶链反应技术检测乳腺肿瘤中EB病毒整合[J].中国癌症杂志,1997,7(2):79-81. |
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作者姓名: | 张丽萍 许良中 |
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作者单位: | 上海市第六人民医院(张丽萍),上海医科大学附属肿瘤医院(许良中) |
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摘 要: | 研究乳腺肿瘤与EB病毒感染之间的关系。方法应用聚合酶链反应检测109例乳腺癌组织中EB病毒DNA整合情况。结果82例乳腺癌中25例有EB病毒整合,20例乳腺纤维腺瘤和7例正常乳腺组织中均无EB病毒DNA整合。乳腺癌组织中EB病毒整合阳性率为30.5%,EB病毒整合与肿瘤淋巴细胞浸润程度无明确关系。结论EB病毒感染与乳腺癌有关。
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关 键 词: | EB病毒 乳腺肿瘤 癌 纤维腺瘤 聚合酶链反应 |
DETECTION OF EPSTEIN BARR VIRUS DNA IN BREAST LESIONS BY PCR |
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Abstract: | PURPOSE To study the relationship between EB virus infection and benign and malignant breast cancer. METHODS The polymerase chain reaction(PCR) was used to identify Epstein Barr virus DNA in 109 cases of normal individuals and patients with breast fibroadenoma and breast cancer. RESULTS EB virus DNA was found in 25 of 82(30.5%) breast cancer cases and none in breast fibroadenoma and normal breast tissue. There was no correlation between EB virus DNA integration and the degree of lymph cell infiltrating in tumor tissues. CONCLUSIONS Epstein Barr virus is associated with breast cancer, but the role of this virus in the carcinogenesis and progression of this disease needs to be studied further. |
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Keywords: | Epstein Barr virus breast neoplasms carcinoma fibroadenoma polymerase chain reaction |
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