| 热休克预处理对家兔肝缺血-再灌注损伤的影响 |
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| 引用本文： | 薄金红,金昊,马志强,张中兴,金肆.热休克预处理对家兔肝缺血-再灌注损伤的影响[J].微循环学杂志,2004,14(3):42-43. |
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| 作者姓名： | 薄金红 金昊 马志强 张中兴 金肆 |
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| 作者单位： | 华中科技大学同济医学院,武汉,430030 |
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| 摘 要： | 目的 :探讨热休克预处理对肝缺血 再灌注损伤的影响。方法 :随机将家兔分为对照组和热休克预处理组 ,复制肝脏缺血 再灌注模型 ,分别于缺血前、缺血 45min、再灌注 45min三次取血 ,赖氏法检测血清谷丙转氨酶 (ALT)活性。结果 :热休克预处理组缺血前的ALT活性稍高于对照组 ,但是缺血后及再灌注后显著低于对照组。结论 :热休克预处理对肝细胞有轻微的损伤作用 ,但是对缺血后和再灌注后损伤均有显著的保护作用。
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| 关 键 词： | 热休克预处理 缺血-再灌注损伤 |
| 文章编号： | 1005-1740(2004)03-0042-02 |
| 修稿时间： | 2003年11月6日 |
Effects of Heat Shock Preconditioning on Liver Ischemia and Reperfusion Injury in Rabbits |
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| Bo Jinhong,Jin Hao,Ma Zhiqiang,et al/Tongji Medical College,Huazhong University of Science and Technology,Wuhan.Effects of Heat Shock Preconditioning on Liver Ischemia and Reperfusion Injury in Rabbits[J].Chinese Journal of Microcirculation,2004,14(3):42-43. |
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| Authors: | Bo Jinhong Jin Hao Ma Zhiqiang /Tongji Medical College Huazhong University of Science and Technology Wuhan |
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| Institution: | Bo Jinhong,Jin Hao,Ma Zhiqiang,et al/Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective: To explore the effects of heat shock preconditioning on liver ischemia and reperfusion.Method: The rabbits were randomly allocated into a heat shock preconditioning group and a control group,then make them into models of liver ischemia and reperfusion. Serum ALT activity was examined through Reitman method before ischemia,at 45 min of ischemia and at 45 min of reperfusion respectively. Results: ALT activity of the heat shock preconditioning group is slightly higher than the control group,but detectable lower than the control group after ischemia and reperfusion.Conclusion: Heat shock preconditioning does nominal harm to the liver cells,but it has significant protective effects on liver ischemia and reperfusion injury. |
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| Keywords: | Heat shock preconditioning Ischemia-reperfusion injury |
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