Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers. |
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| Authors: | Y Hida T Morita M Fujita Y Miyasaka S Horita Y Fujioka K Nagashima H Katoh |
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| Affiliation: | Second Department of Surgery, School of Medicine, Hokkaido University, Kita-Ku, Sapporo 060-8638, Japan. |
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| Abstract: | Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis. |
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