Pulmonary and mediastinal lesions in children with Langerhans cell histiocytosis |
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Authors: | Anne Smets Koen Mortelé Gunther De Praeter Olivier François Yves Benoit Marc Kunnen |
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Institution: | (1) Department of Radiology, University Hospital Gent, Gent, Belgium, BE;(2) Department of Pediatric Hemato-oncology, University Hospital Gent, Gent, Belgium, BE;(3) Department of Radiology, University Hospital of Utrecht, P0 Box 85500, 3508 GA Utrecht, The Netherlands, NL |
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Abstract: | Langerhans cell histiocytosis (LCH) is an uncommon group of disorders affecting mainly children and young adults. In children,
pulmonary involvement occurs mostly in the disseminated forms; isolated pulmonary lesions are unusual. A retrospective study
was undertaken on a group of 42 children diagnosed with LCH over a 19-year period. Eight children (19 %) had radiological
evidence of pulmonary involvement. The lung lesions were either present at the time of diagnosis or, when appearing during
the course of the disease, always coinciding with exacerbation or recurrence of the disease in other sites. Lung involvement
did not appear to be an unfavourable prognostic factor. However, the toxic effects of treatment on the lungs might lead to
important pulmonary sequelae.
Received: 3 February 1997 Accepted: 23 June 1997 |
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