放松训练与帕罗西汀联合治疗强迫症的对照研究

目的:探讨放松训练与帕罗西汀联合治疗强迫症的的疗效及安全性.方法:将56例强迫症患者随机分为观察组和对照组,每组28例.观察组采用放松训练和帕罗西汀治疗,对照组单纯以帕罗西汀治疗,疗程3个月.采用Y-BOCS、CGI-SI、HAMD、TESS等量表评定疗效及安全性.结果:在治疗后第4、8周及半年随访时,观察组Y-BOCS、CGI-SI、HAMD等量表评分均显著低于对照组(P＜0.05),两组不良反应比较差异无显著性(P＞0.05).结论:放松训练与帕罗西汀联合治疗强迫症的疗效优于单用帕罗西汀.

A CONTROLLED STUDY OF RELAXATION TRAINING COMBINED WITH PAROXETINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER

Objective:To evaluate the efficacy and safety of Relaxation training combined with Paroxetine in the treatment of obsessive-compulsive disorder(OCD).Methods:Fifty-six patients with OCD were randomized to two groups.The patients(n=28)in observed group were treated with Relaxation training combined with Paroxetine.The patients(n=28)in control group were treated with Paroxetine alone.The efficacy and safety were assessed with Y-BOCS,CGI-SI,HAMD and TESS scales.Results:The scores of Y-BOCS,CGI-SI and HAMD scales in observed group were significantly lower than that in control group at the end of 4 weeks,8 weeks and 6 month after the treatment(P<0.05,respectively).There was no significant difference in side effects between the two groups(P>0.05).Conclusion:Relaxation training combined with Paroxetine was more effective than Paroxetine mono-therapy in thetreatment of OCD.