麻疹病毒致病机制研究进展

麻疹是由麻疹病毒（MV）引起的急性传染性疾病。MV主要通过CD150受体感染免疫细胞（如DCs），在胞内增殖后再感染局部淋巴结，随淋巴回流感染全身。致病过程易引起机体免疫抑制，主要是由病毒致淋巴细胞和DC损伤、下调IL-12的合成、改变IFN信号通路等原因引起。MV结构蛋白的变异也能引起机体免疫抑制。此外，MV基因突变等所致的改变还易引发人体亚急性硬化性全脑炎（SSPE）等慢性感染。此文就MV致病机制作一综述，以期为临床采取更有针对性的治疗提供参考。

Advances on pathogenic mechanism of measles virus

Measles is an acute infectious disease which is caused by measles virus （MV）. MV can infect immunocytes such as dendritic cells （DCs） through CD150 receptor, and then infect regional lymph nodes after its reproduction in DCs, and finally cause systemic infection with lymphatic drainage. Immune suppression is usually developed after infection of MV due to lymphocyte and DC damage, down-regulation of IL-12 generation, and the IFN signaling pathway change. The variation of MV structural protein can also induce immune suppression. Be- sides, gene mutations of MV are prone to develop subacute sclerosing panencephalitis （SSPE） and other chronic infections. The advances on the pathogenic mechanism of MV are reviewed in the article.