丁卡因胶浆在经直肠前列腺穿刺活检中的临床应用价值

目的 比较患者在行经直肠前列腺穿刺活检术时,在直肠内及肛周使用丁卡因胶浆或单纯润滑剂,患者所经历的疼痛情况.方法 回顾性分析2011年1月至2013年1月120例行经直肠前列腺穿刺患者的临床资料.其中术中采用单纯性润滑剂患者60例（组Ⅰ）,采用丁卡因胶浆患者60例（组2）.采用水平视觉疼痛评分法评估患者经历的疼痛程度.结果 通过组间比较,两组患者疼痛程度与患者年龄、PSA水平、DRE是否异常、穿刺数目及术后并发症发生等均无统计学意义（P＞0.05）,当穿刺器械进入肛门时患者疼痛不适评分组1为2.8±1.8分,组2为1.3±1.6分（P=0.000＜0.05）,当行前列腺穿刺活检术时患者疼痛不适评分组1为5.5±1.7分,组2为3.3±1.5分（P=0.211 ＞0.05）.结论 麻药制剂并不能增加经直肠前列腺穿刺活检术的安全性,但采用麻药制剂（如丁卡因胶浆）后可明显减轻穿刺所带给患者的疼痛不适.

Tetracaine Hydrochloride Jelly for clinical value during Transrectal Ultrasound guided biopsy of the prostate

Objectives The aim of this study was to compare the level of pain experienced by patients during TRUS-guided prostate biopsy using intrarectal 1% Tetracaine Hydrochloride Jelly versus Liquid paraffin.Methods 120 men using intrarectal 1% Tetracaine Hydrochloride Jelly versus Liquid paraffin in a protocol for prostate-cancer screening were analyzed.In this study we compared the pain and discomfort associated with prostate biopsy between two group of patient.Group 1 consists of 60men who received simple Liquid paraffin,and group 2 consists of 60 men who were given 1% Tetracaine Hydrochloride Jelly before the biopsy.Pain score measured by horizontal visual analogue scales.Results There were no statistical differences between the two groups in terms of age,serum PSA,DRE,TURS,biopsy core number and complications after biopsy（P 〉 0.05）.The average pain score at the time of insertion of the ultrasound probe were 28 ± 1.8 and 1.3 ± 1.6 （P =0.000 〈 0.05） and the average pain score at the time of taking biopsy were 5.5 ± 1.7and 3.3 ± 1.5 （P =0.211 〉 0.05）,respectively.Conclusions TRUS-guided prostate biopsy of the prostate can be safely whether or not anaesthesia in patients.But used 1% Tetracaine Hydrochloride Jelly in the rectal and perianal before TURS-guided prostate biopsy is an effective method for relieving biopsy-relate pain during the procedure.