| The Relationship among Polymorphism of Promotor of PAI-1 Gene,Type 2 Diabetes Mellitus,Hypertension and Coronary Heart Disease |
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| 引用本文： | DING Guo-xian,SHEN Jie,CHEN Jia-wei(Department of Geriatrics,Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China ). The Relationship among Polymorphism of Promotor of PAI-1 Gene,Type 2 Diabetes Mellitus,Hypertension and Coronary Heart Disease[J]. 南京医科大学学报(英文版), 2003, 0(1) |
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| 作者姓名： | DING Guo-xian SHEN Jie CHEN Jia-wei(Department of Geriatrics Department of Endocrinology the First Affiliated Hospital of NJMU Nanjing 210029 China ) |
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| 作者单位： | Department of Geriatrics，Department of Endocrinology，the First Affiliated Hospital of NJMU，Nanjing 210029，China |
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| 摘 要： | Objective:To explore the relationship between polymorphism of PAI-1 gene and type 2 diabetes mellitus(DM} , hyperten-sion, and coronary heart disease. Methods: The polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene was analyzed by PCRtechnique in 281 subjects. Results: The frequency uf 4G/ 4G genotype and 4G allele uf PAI- 1 in type 2 diabetic patients were in-creased compared with non-diabetic subjects(X2 = 6. 0 and 6. 3 respectively,P<0. 05). In DM group, the frequency of 4G/4.G geno-type and 4G allele of PAI-1 in patients with coronary heart disease were significantly increased than in patients without coronary heart dis-ease (X2 = 6. 9 and 7. 6 respectively,P<0. 05 ,P<0. 01 respecitively). In the model uf multiple factors non-conditional logistic re-gression analyses,coronary lieart disease related to age, obesity ard 'polymorphism of PAI-1(P<0. 001, P<0. 05,P<0. 01 respec-tively). Conclusion :These results suggested that the 4G allele uf PAI-1 gene might be a risk factor of type 2 diabe
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The Relationship among Polymorphism of Promoter of PAI-1 Gene, Type 2 Diabetes Mellitus, Hypertension and Coronary Heart Disease |
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| DING Guo-xian,SHEN Jie,CHEN Jia-wei. The Relationship among Polymorphism of Promoter of PAI-1 Gene, Type 2 Diabetes Mellitus, Hypertension and Coronary Heart Disease[J]. Journal of Nanjing Medical University, 2003, 0(1) |
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| Authors: | DING Guo-xian SHEN Jie CHEN Jia-wei |
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| Abstract: | bjective:To explore the relationship between polymorphism of PAI-1 gene and type 2 diabetes mellitus(DM} , hyperten-sion, and coronary heart disease. Methods: The polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene was analyzed by PCRtechnique in 281 subjects. Results: The frequency uf 4G/ 4G genotype and 4G allele uf PAI- 1 in type 2 diabetic patients were in-creased compared with non-diabetic subjects(X2 = 6. 0 and 6. 3 respectively,P<0. 05). In DM group, the frequency of 4G/4.G geno-type and 4G allele of PAI-1 in patients with coronary heart disease were significantly increased than in patients without coronary heart dis-ease (X2 = 6. 9 and 7. 6 respectively,P<0. 05 ,P<0. 01 respecitively). In the model uf multiple factors non-conditional logistic re-gression analyses,coronary lieart disease related to age, obesity ard 'polymorphism of PAI-1(P<0. 001, P<0. 05,P<0. 01 respec-tively). Conclusion :These results suggested that the 4G allele uf PAI-1 gene might be a risk factor of type 2 diabetes disease compli-cated with coronary heart disease. |
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| Keywords: | PAI-1 type 2 diabetes mellitus hypertension coronary heart disease |
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