Gut microbiota and liver diseases |
| |
Authors: | Masami Minemura Yukihiro Shimizu |
| |
Affiliation: | Masami Minemura, the Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanYukihiro Shimizu, Gastroenterology Center, Nanto Municipal Hospital, Toyama 932-0211, Japan |
| |
Abstract: | Several studies revealed that gut microbiota are associated with various human diseases,e.g.,metabolic diseases,allergies,gastroenterological diseases,and liver diseases.The liver can be greatly affected by changes in gut microbiota due to the entry of gut bacteria or their metabolites into the liver through the portal vein,and the liver-gut axis is important to understand the pathophysiology of several liver diseases,especially non-alcoholic fatty liver disease and hepatic encephalopathy.Moreover,gut microbiota play a significant role in the development of alcoholic liver disease and hepatocarcinogenesis.Based on theseprevious findings,trials using probiotics have been performed for the prevention or treatment of liver diseases.In this review,we summarize the current understanding of the changes in gut microbiota associated with various liver diseases,and we describe the therapeutic trials of probiotics for those diseases. |
| |
Keywords: | Gut microbiota Immune system Liver disease Metabolites Non-alcoholic fatty liver disease Hepatic encephalopathy |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 |
|