莫西沙星与阿莫西林对幽门螺杆菌根除率的对比研究

目的比较莫西沙星与阿莫西林对幽门螺杆菌根除率的临床疗效。方法采用平行对照实验设计，入选幽门螺杆菌阳性的消化性溃疡患者102例，随机分为2组：莫西沙星组（n=52）和阿莫西林组（n=50）。莫西沙星组给予埃索美拉唑20mgbid、构椿酸铋雷尼替丁0．4gbid、莫西沙星（拜复乐）0．4gqd和替硝唑0．5gbid；阿莫西林组给予埃索美拉唑20nagbid、构橼醒铋雷尼替丁0．4gbid、阿莫西林1．0gbid和替硝唑0．5gbid。2组疗程均为7天。治疗结束4周后采用^13 C呼气实验（^13 C-UBT）检查患者幽门螺杆菌的情况。结果莫西沙星组幽门螺杆菌的根除率高于阿莫西林组（94．2％vs80．096），具有显著性差异（P〈0．05）。结论莫西沙星对幽门螺杆菌的根除率明显优于阿莫西林。

Comparative study of H. pylori eradication rate between moxifloxacin and amoxicillin

OBJECTIVE To study the difference of H. pylori eradication rate between moxifloxacin and amoxicillin. METHODS In this parallel control study, 102 H. pylori-positive peptic ulcer patients were divided into moxifloxacin group（n = 52, taking esomeprazole 20 mg bid, ranitidine bismuth citrate capsules 0.4 g bid, moxi- floxacin 0.4 g qd, tinidazole 0.5 g bid） and amoxicillin group （n = 50, taking esomeprazole 20 mg bid, ranitidine bismuth citrate capsules 0.4 g bid, amoxicillin 1.0 g bid, tinidazole 0.5 g bid）for 7 days. H. pylori status was as- sessed 4 weeks after the end of treatment by 13C urea breath teat（C-UBT）. RESULTS The rate of H. pylori eradication in moxifloxacin group was higher than that in amoxicillin group（94.2 % vs 80.096, P 〈 0.05 ）. CONCLUSION The rate of H. pylori eradication in moxifloxacin is better than that in amoxiciUin.