| 河南省艾滋病病毒感染者HIV毒株膜蛋白基因序列研究 |
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| 引用本文： | 王哲,韩卫国,王春俭,李宏,崔为国,薛晓玲,苏玲,刑辉,龚新昌,邵一鸣. 河南省艾滋病病毒感染者HIV毒株膜蛋白基因序列研究[J]. 中国艾滋病性病, 1999, 0(4) |
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| 作者姓名： | 王哲 韩卫国 王春俭 李宏 崔为国 薛晓玲 苏玲 刑辉 龚新昌 邵一鸣 |
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| 作者单位： | 河南省卫生防疫站，河南省卫生防疫站，河南省卫生防疫站，河南省卫生防疫站，河南省卫生防疫站，河南省卫生防疫站，卫生部艾滋病预防与控制中心，卫生部艾滋病预防与控制中心，卫生部艾滋病预防与控制中心，卫生部艾滋病预防与控制中心 郑州市450003，郑州市450003，郑州市450003，郑州市450003，郑州市450003，郑州市450003 |
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| 摘 要： | 对河南省部分地区HIV-1感染者提取外周血单核细胞(PBMC)DNA,经套式PCR扩增env基因片断,对C2—V3区350—450核苷酸序列进行测定和分析.结果表明所采样品均属HIV—1B亚型,与其它国际亚型的基因离散率在20%以上;与流行于云南省的B亚型毒株基因离散率为2.8%左右,样品间的基因离散率很小.结果提示,流行于河南省的HIV属B亚型,并与云南省的流行株密切相关;其在河南省的流行时间在3年左右.
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| 关 键 词： | 人类获得性免疫缺陷病毒Ⅰ型 基因亚型 变异 |
Subtype and C2-V3 Region Sequence Analysis on HIV-1 in Henan |
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| Wang Zhe,Su Ling,Han Weiguo,Wang Chunjian,et al.. Subtype and C2-V3 Region Sequence Analysis on HIV-1 in Henan[J]. Chinese JOurnal of Aids & STD, 1999, 0(4) |
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| Authors: | Wang Zhe Su Ling Han Weiguo Wang Chunjian et al. |
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| Affiliation: | Wang Zhe,Su Ling,Han Weiguo,Wang Chunjian,et al. Department of STD/AIDS,Henan Health and Anti-epidemic Center,Zhengzhou 450003 |
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| Abstract: | Six DNA fragments of HIV-1 env gene were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from HIV - 1 positive people of Henan province in 1998. The C2 -V3 region (about 450bp) were sequenced. The results showed that all of them are HIV-1 subtype B with 2.9% gene divergence innergroup. After being compared with sequences of several reference HIV-1 strains, It was closely related to that identified in Yunnan. The epidemic time of it in Henan was estimated to be about three years. |
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| Keywords: | HIV-1 Genomic subtype Variability |
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