| 美罗培南的体外抗菌活性研究 |
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| 引用本文： | 顾怡明,张杰,唐明忠,杜小玲. 美罗培南的体外抗菌活性研究[J]. 中国抗生素杂志, 2003, 28(12): 761-763 |
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| 作者姓名： | 顾怡明 张杰 唐明忠 杜小玲 |
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| 作者单位： | 1. 北京天坛医院,北京,100050
2. 北京朝阳医院,北京,100020 |
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| 摘 要： | 目的 评价国产美罗培南对产β-内酰胺酶细菌的体外抗菌活性。方法 琼脂稀释法测定美罗培南对110株产β-内酰胺酶临床分离菌的最低抑菌浓度(MIC)。并与相关抗菌药物进行比较。结果 碳青霉烯类抗生素对产β-内酰胺酶菌株具有高度抗菌活性，国产美罗培南作用略强于亚胺培南。碳青霉烯类抗生素体外抗菌作用优于头霉素、第四代头孢菌素、β-内酰胺类抗生素与β-内酰胺酶抑制剂合剂、喹诺酮类和氨基糖苷类药物。结论 国产美罗培南是治疗产β-内酰胺酶细菌所致感染的理想药物。
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| 关 键 词： | 美罗培南 β-内酰胺酶 体外抗菌活性 碳青霉烯类抗生素 抑菌浓度 |
| 文章编号： | 1001-8689(2003)12-0761-03 |
In vitro antibacterial activity of meropenem |
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| Gu Yi-ming,Zhang Jie,Tang Ming-zhong and Du Xiao-ling. In vitro antibacterial activity of meropenem[J]. Chinese Journal of Antibiotics, 2003, 28(12): 761-763 |
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| Authors: | Gu Yi-ming Zhang Jie Tang Ming-zhong Du Xiao-ling |
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| Affiliation: | Gu Yi-ming1,Zhang Jie1,Tang Ming-zhong1 and Du Xiao-ling2 |
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| Abstract: | Objectives To investigate the in vitro antimicrobial activity of m eropenem. Methods The minimum inhibitory concentrations (MICs) of meropenem agai nst 110 clinical isolates producing a-lactamases were determined by agar dil ution method,in comparison to 10 other antimicrobial agents. Results Carbapenems were highly active against clinical isolates producing a-lactamases.Meropen em activity against clinical isolates was slightly superior to imipenem, and sup erior to those of cephamycin, the forth generation cephalosporins, a-lactam and a-lactamase inhibitor preparations, fluroquinolones and aminogiycosides. Conclusion Meropenem is a drug of choice in treating infections caused by isolat es producing a-lactamases. |
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| Keywords: | Meropenem a-lactamases In vitro antibacterial activity |
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