DF方案治疗30例老年晚期胃癌的疗效观察

目的观察多西他赛（DOC）联合5-氟尿嘧啶（5-Fu）和亚叶酸钙（CF）（简称DF方案）治疗老年晚期胃癌的临床疗效及不良反应。方法对30例老年晚期胃癌患者,采用DOC75mg/m2,静脉滴注,第1天;CF200mg/m2静脉滴注,第1天,2h后5-Fu500mg静脉推注,随后5-Fu2500mg/m2持续48h化疗泵静脉内注入,21天为1个周期,2周期后评价疗效。结果 30例患者均可评价疗效,其中完全缓解3例,部分缓解13例,稳定9例,进展5例,有效率53.3%,中位疾病进展时间为5.4个月,中位生存期10.8个月。不良反应主要是骨髓抑制、胃肠道反应和手足综合征,均为可逆性,无治疗相关性死亡。结论 DF方案治疗老年晚期胃癌疗效好,不良反应轻,患者耐受性好,值得临床推广。

Observation of curative effect of docetaxel combined with Fluorouracil and Calcium Folinate in treatment of 30 cases of elderly patients with advanced gastric cancer

Objective To observe the clinical efficacy and adverse reactions of the combination of docetaxel （DOC）,Fluorouracil （5-Fu） and Calcium Folinate （CF） （DF project for short）in the treatment of elderly patients with advanced gastric cancer.Methods 30 patients with advanced gastric cancer were treated with DOC 75 mg/m2,CF 200 mg/m2 iv the first day,and 5-Fu 500mg iv after 2 hours,then injected 5-Fu 2500 mg/m2 through a vena pump continuously for 48 hours;repeated every 3 weeks （as a therapeutic cycle）,The effect was evaluated after two cycles.Results clinical response was evaluated in 30 patients.3 patients completely response,13 patients partially response,9 at the stable stage and 5 progression were observed with an overall response rate of 53.3%,The median time of progression was 5.4 months and median survival time were 10.8 months.The most common toxicities were bone marrow suppression,vomiting and Hand-foot-syndrome.All of them are reversible.There was no treatment related death.Conclusion Combining DOC with 5-Fu and CF is an effective and better tolerated alternative treatment on elderly patients with advanced gastric cancer and yields promising activity.