东莞市478例肺结核患者原始耐药监测

目的监测东莞市分枝杆菌原始耐药情况,制定科学的防治对策。方法采用WHO制定的结核分枝杆菌耐药监测方案开展东莞市结核分枝杆菌耐药监测,使用比例法对478例新发现无抗结核用药史的441例菌阳肺结核患者的耐药性进行测定。结果441例患者中,原始耐药者101例,总耐药率为22.9%.各药的原始耐药率分别为异烟肼(H):15.19%,利福平(R):10.43%,链霉素(S):12.93%,乙胺丁醇(E):5.22%;原始耐多药率分别为:HR7.94%,HRS4.08%,HRE3.63%,HRSE2.27%。结论本地区结核分枝杆菌原始耐药现状较严重,须进一步加强结核病控制规划。

Surveillance of Primary Resistance in 478 Cases of Pulmonary Tuberculiosis

Objective To understand the primary resistance of Mycobacterium tuberculosis in Dong Guan,and to make scientific prophylactic and treatment strategies.Method Drug resistance Surveillance(DRS) Was implemented in Dong Guan according to WHO/IUATLD Guidelines for Surverllance of Drug Resistance in Tuberculosis(1994),and proportional method was used to detect primary resistance in the 441 cases of 478 new cases with bacillus-positive pulmonary tuberculosis without history of anti-tuberculosis drug use.Result The101 cases of 441 sickness.is the primary drug resistance(PDR) cases. The primary drug resistance(PDR) rates were 15.19%,10.43%,12.93%,5.22% for H.R.S and E respectively.The primary multi-drug resistance(MDR) rates were 7.94%,4.08%,3.63%,and 2.27% for HR,HRS,HRE and HRSE,respectively.Conclusion The results show that the problem of primary resistance of Mycobacterium tuberculosis is serious in Dong Guan,and National TB control program should be further strengthened.