Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities |
| |
Authors: | Sabbaj Steffanie Bansal Anju Ritter G Douglas Perkins Christopher Edwards Bradley H Gough Ethan Tang Jianming Szinger James J Korber Bette Wilson Craig M Kaslow Richard A Mulligan Mark J Goepfert Paul A |
| |
Affiliation: | Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. sabbaj@uab.edu |
| |
Abstract: | Vaccines designed to bring forth CD8+ T cell responses in different racial and ethnic groups will require inclusion of T cell epitopes presented by various MHC class I molecules. This study was designed to identify new CD8+ T cell epitopes in HIV-infected African American and Hispanic youth as well as to determine the frequency of responses to both novel and previously described HIV-1 epitopes in a cohort of racially and ethnically diverse individuals. We found 8 MHC class I-restricted CD8+ T cell epitopes that had not been previously described, another 8 epitopes that were restricted by class I alleles not previously associated with these epitopes, and 8 additional epitopes that have been described previously. In a larger cohort, we demonstrated that 11 (69%) of these 16 newly described immunogens were recognized by individuals of different race or ethnicity. Most HIV-1-specific CD8+ T cell epitopes identified were either novel or restricted by alternative MHC class I alleles. Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|