| 硝苯地平海藻酸钙凝胶缓释微丸处方及工艺的优化 |
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| 引用本文： | 马萍,孙淑英,辛艳茹,梁冬梅,高文静. 硝苯地平海藻酸钙凝胶缓释微丸处方及工艺的优化[J]. 沈阳药科大学学报, 2003, 20(6): 405-408 |
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| 作者姓名： | 马萍 孙淑英 辛艳茹 梁冬梅 高文静 |
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| 作者单位： | 1. 第二炮兵总医院药剂科,北京,100088
2. 沈阳药科大学药学院,辽宁沈阳,100016 |
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| 摘 要： | 目的制备硝苯地平 海藻酸钙凝胶缓释微丸。方法采用滴制法。用单因素考察及均匀设计实验优化处方及工艺。结果优化得到的微丸在体外累计释放硝苯地平百分率 ,2h为 2 0 %～ 3 0 % ,6h为 60 %～ 80 % ,1 2h>85 %。结论在体外释放度实验中 ,硝苯地平海藻酸钙凝胶微丸具有良好的缓释作用
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| 关 键 词： | 硝苯地平 海藻酸钙 凝胶微丸 缓释制剂 |
| 文章编号： | 1006-2858(2003)06-0405-04 |
| 修稿时间： | 2002-06-11 |
Optimizing the formulation and their process of the sustained-release Ca-alginate gel pellets of nifedipine |
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| MA Ping ,SUN Shu-ying ,XIN Yan-ru ,LIANG Dong-mei ,GAO Wen-jing. Optimizing the formulation and their process of the sustained-release Ca-alginate gel pellets of nifedipine[J]. Journal of Shenyang Pharmaceutical University, 2003, 20(6): 405-408 |
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| Authors: | MA Ping SUN Shu-ying XIN Yan-ru LIANG Dong-mei GAO Wen-jing |
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| Affiliation: | MA Ping 1,SUN Shu-ying 2,XIN Yan-ru 1,LIANG Dong-mei 1,GAO Wen-jing 1 |
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| Abstract: | Objective To prepare the sustained-release Ca-alginate gel pellets of nifedipine (NP).Methods The sustained-release pellets were prepared by the dropping method.The formulation and process were optimized with the simple factor investigation and the uniformity design.Results The accumulation dissolution percentage in vitro of NP from the sustained-release gel pellets was 20%～30% at 2 h, 60%～80% at 6 h, greater than 85% at 12 h.Conclusions It is showed that NP-Ca-alginate gel pelltes have good sustained-release results. |
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| Keywords: | nifedipine calcium alginate gel pellets sustained |
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