Association of a wide invasive malignant thymoma with myastenia gravis and primary hyperparathyroidism due to parathyroid adenoma: case report and review of the literature |
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| Authors: | Triggiani Vincenzo Guastamacchia Edoardo Lolli Ivan Troccoli Giuseppe Resta Francesco Sabbà Carlo Ruggieri Nadia Tafaro Emilio |
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| Affiliation: | a Endocrinology and Metabolic Diseases, Department of Application of Innovative Technology in Surgery, University of Bari, Bari, Italyb Internal Medicine, Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italyc Medical Oncology, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italyd Geriatrics and Gerontology, Department of Internal Medicine, Immunology and Infectious Disease, University of Bari, Bari, Italye Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy |
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| Abstract: | There are few cases described in the world literature reporting an association of thymoma (with myasthenia gravis or not) with hyperparathyroidism. In these cases the hyperparathyroidism was due to the presence of an adenoma or hyperplasic parathyroid tissue either in the cervical region or in an ectopic intrathymic location.(1-51, 5) In other cases the syndrome of hypercalcemia was due to the secretion of parathyroid-related protein (PTHRP) (6) or parathyroid hormone (PTH) (7) by the thymoma itself. We report the first case, at the best of our knowledge, of a wide invasive malignant thymoma (type B3), associated with myasthenia gravis and hyperparathyroidism caused by parathyroid adenoma. |
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