Nonrandom cytogenetic changes in New Zealand patients with acute myeloid leukemia |
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Authors: | P H Fitzgerald C M Morris G J Fraser L M Giles J W Hamer D C Heaton M E Beard |
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Institution: | 1. Cancer Society of New Zealand, Cytogenetics Unit, Christchurch Hospital, Christchurch, New Zealand;2. Department of Haematology, Christchurch Hospital, Christchurch, New Zealand. |
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Abstract: | Bone marrow clones with abnormal chromosomes were observed in 56% of 66 patients with forms of acute myeloid leukemia French-American-British (FAB) M1-M6]. Acute myeloblastic leukemia (AML, M1 and M2) was the most common form, and 65% of these patients showed chromosomal abnormalities compared with 41% of patients with acute myelomonocytic leukemia (AMMoL, M4). The recognized nonrandom chromosomal abnormalities found were trisomy 8, monosomy 5 or 7, trisomy 1q, t(6;9), t(8;21), t(15;17), and abnormalities in 17q. There was also a strong involvement of chromosome No. 11: Abnormalities were found in eight patients when their leukemia was diagnosed and in a further three patients during the course of karyotypic evolution. Six of these patients had AMMoL or AMoL. Complex or multiple clones were found in 37% of AML patients at diagnosis. Our AML patients had a reduced frequency of abnormalities in chromosome No. 5 or 7 and an increased frequency of abnormalities in chromosome No. 8 compared with studies reported in other countries (p = 0.01). This difference suggests that in New Zealand AML might be caused by factors different from those operating in more industrialized centers. |
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Keywords: | Address requests for reprints to Dr P H Fitzgerald Cancer Society of New Zealand Cytogenetics Unit Christchurch Hospital Christchurch New Zealand |
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