| 溴新斯的明缓释片的药动学及相对生物利用度 |
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| 作者姓名： | Xiong HR Tan QY Liu BL Luo W Zhang JQ |
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| 作者单位： | 1. 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室 重庆400016
2. 第三军医大学大坪医院野战外科研究所胸外科 重庆400042 |
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| 基金项目： | 教育部博士点基金(20095503120008); 重庆市教育委员会(首批高等学校优秀人才资助,KJ090308)资助 |
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| 摘 要： | 目的 研究溴新斯的明普通片与缓释片在新西兰兔体内的药动学和相对生物利用度.方法 6只健康新西兰兔随机分成2组,进行双交叉自身对照试验.用反相高效液相色谱法测定兔血浆中的药物浓度,采用DAS 2.0软件处理计算主要药动学参数.结果 溴新斯的明缓释片与普通片的主要药动学参数为:达峰时间(peak time,Tmax)分别为...
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| 关 键 词： | 溴新斯的明 高效液相色谱法 药动学 相对生物利用度 |
Pharmacokinetics and relative bioavailability of neostigmine bromide sustained-release tablets |
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| Xiong HR,Tan QY,Liu BL,Luo W,Zhang JQ.Pharmacokinetics and relative bioavailability of neostigmine bromide sustained-release tablets[J].Journal of West China University of Medical Sciences,2011,42(5):657-660. |
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| Authors: | Xiong Hua-Rong Tan Qun-You Liu Bi-Lin Luo Wen Zhang Jing-Qing |
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| Institution: | XIONG Hua-rong1,TAN Qun-you2,LIU Bi-lin1,LUO Wen1,ZHANG Jing-qing1.1.Medicine Engineering Research Center,Chongqing Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China,2.Department of Thoracic Surgery,the Daping Hospital & Research Institute of Surgery,the Third Military Medical University,Chongqing 400042 |
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| Abstract: | Objective To study the pharmacokinetics and relative bioavailability of neostigmine bromide conventional tablets and sustained-release tablets in rabbits.Methods Six healthy rabbits were randomly divided into two groups for a cross self-contrast trial.RP-HPLC was used to detect plasma concentrations of neostigmine bromide.The pharmacokinetic parameters were calculated with the aid of DAS 2.0 software.Results The main pharmacokinetics parameters of the sustained-release tablets and conventional tablets were ... |
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| Keywords: | Neostigmine bromide HPLC Pharmacokinetics Relative bioavailability |
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