| 鼠尾草酸联合1,25-二羟基维生素D3对NB4细胞的影响 |
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| 引用本文： | 曲辉,付姝丽,任立红,庄德丽,孙晓晗. 鼠尾草酸联合1,25-二羟基维生素D3对NB4细胞的影响[J]. 哈尔滨医科大学学报, 2011, 45(5): 416-420 |
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| 作者姓名： | 曲辉 付姝丽 任立红 庄德丽 孙晓晗 |
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| 作者单位： | 哈尔滨医科大学附属第二医院儿内科,黑龙江哈尔滨,150081 |
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| 基金项目： | 黑龙江省卫生厅资助项目(2006-092) |
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| 摘 要： | 目的 研究鼠尾草酸(carnosic acid,CA)与1,25-二羟基维生素D3[1,25( OH)2D3]联合应用对NB4细胞生长及凋亡、分化的诱导作用.方法 通过四氮唑蓝(MTT)法观察细胞的生长,光学显微镜观察细胞形态,应用流式细胞仪测定细胞周期、凋亡率及CD14的表达,观察联合应用鼠尾草酸与低浓度1,25(O...
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| 关 键 词： | 鼠尾草酸 1,25-二羟基维生素D3 NB4细胞 凋亡 分化 |
Effects on NB4 cells of carnosic acid in combination with 1,25-dihydroxyvitamin D_3 |
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| QU Hui,FU Shu-li,REN Li-hong,ZHUANG De-li,SUN Xiao-han. Effects on NB4 cells of carnosic acid in combination with 1,25-dihydroxyvitamin D_3[J]. Journal of Harbin Medical University, 2011, 45(5): 416-420 |
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| Authors: | QU Hui FU Shu-li REN Li-hong ZHUANG De-li SUN Xiao-han |
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| Affiliation: | QU Hui,FU Shu-li,REN Li-hong,ZHUANG De-li,SUN Xiao-han(Department of Pediatrics,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China) |
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| Abstract: | Objective To study the effects of carnosic acid combined with 1,25-dihydroxyvitamin D3 on the growth,apoptosis and differentiation of human acute promylocytic leukemia(APL)cell line NB4.Methods The proliferation of NB4 cells was examined by MTT assay.The changes of morphologic features of NB4 cells were observed by microscope;meanwhile,cell cycle parameters and monocytic differentiation marker CD14 were detected by flow cytometry.Results After exposed to carnosic acid or/and 1,25-dihydroxyvitamin D3,the cel... |
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| Keywords: | carnosic acid 1 25-dihydroxyvitamin D3 NB4 cells apoptosis differentiation |
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