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| 鼻用黄芩苷磷脂复合物原位凝胶对鼻黏膜的毒性研究 | |
| 引用本文： | 李楠,叶英杰,杨明,蒋学华.鼻用黄芩苷磷脂复合物原位凝胶对鼻黏膜的毒性研究[J].华西药学杂志,2011,26(5):469-470. |
| 作者姓名： | 李楠 叶英杰 杨明 蒋学华 |
| 作者单位： | 1. 成都中医药大学药学院,四川成都611137;四川大学华西药学院,四川成都610041 2. 成都中医药大学药学院,四川成都,611137 3. 江西中医学院中药现代制剂教育部重点实验室,江西南昌,330004 4. 四川大学华西药学院,四川成都,610041 |
| 摘 要： | 目的 评价黄芩苷磷脂复合物原位凝胶经鼻给药的鼻黏膜毒性.方法在体蟾蜍药物对纤毛运动的影响,用溶血实验考察药物对生物膜的作用.结果黄芩苷磷脂复合物原位凝胶对蟾蜍鼻纤毛的运动几乎无影响,纤毛运动时间相对百分率约90.1%,并不产生溶血反应.结论黄芩苷磷脂复合物原位凝胶鼻腔给药无明显毒性,经鼻给药的开发是可行的. |
| 关 键 词： | 黄芩苷磷脂复合物 鼻用原位凝胶 鼻黏膜 鼻腔给药 黏膜毒性 |
Toxicity evaluation of Baicalin-phospholipid nasal in situ gel on nasal mucosa |
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| LI Nan , YE Ying-jie , YANG Ming , JIANG Xue-hua.Toxicity evaluation of Baicalin-phospholipid nasal in situ gel on nasal mucosa[J].West China Journal of Pharmaceutical Sciences,2011,26(5):469-470. | |
| Authors: | LI Nan YE Ying-jie YANG Ming JIANG Xue-hua |
| Institution: | LI Nan1,2,YE Ying-jie1,YANG Ming3,JIANG Xue-hua2* (1.Chengdu University of TCM,Chengdu,Sichuan,611137 P.R.China,2.West China School of Pharmacy,Sichuan University,610041 P.R.China,3.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Nanchang,Jiangxi,330004 P.R.China) |
| Abstract: | OBJECTIVE To investigate the toxicity of Baicalin-phospholipid nasal in situ gel(BPG).METHODS The effects of BPG on nasal cilia movement were tested with palate of isolated toad,and the effects on biomembrane were observed by hemolytic tests.RESULTS There were no significant effects of BPG on the nasal ciliarymovement,the relative percentage of the lasting time of ciliary movement was 90.1% approximately.And BPG showed no hemolytic effect.CONCLUSION The BPG has no significant toxicity on nasal mucosa and ca... |
| Keywords: | Baicalin-phospholipid Nasal in situ gel Nasal mucosa Intranasal administration Mucosal toxicity |
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