| 重组人血管内皮抑制素壳聚糖纳米粒的制备 |
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| 引用本文： | 李玲,王青松,刘春晖,许向阳.重组人血管内皮抑制素壳聚糖纳米粒的制备[J].华西药学杂志,2011,26(5):414-416. |
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| 作者姓名： | 李玲 王青松 刘春晖 许向阳 |
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| 作者单位： | 江苏先声药物研究有限公司,江苏南京,210042 |
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| 基金项目： | 江苏省自然科学基金(项目编号:BK2008515) |
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| 摘 要： | 目的 以壳聚糖(CS)为载体,研究其对重组人血管内皮抑制素(Endostar)的包封及控释能力.方法采用大分子复合法制备纳米粒,考察形成条件及冻干工艺,并对纳米粒的形态、包封率、体外释放及Endostar的完整性进行考察.结果CS与羧甲基纤维素钠( CMC - Na)的质量比介于6∶1～1∶2时可以形成纳米粒,粒径为1...
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| 关 键 词： | 重组人血管内皮抑制素 壳聚糖 羧甲基纤维素钠 纳米粒 |
Preparation of Chitosan nanoparticles containing Endostar |
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| LI Ling,WANG Qing-song,LIU Chun-hui,XU Xiang-yang.Preparation of Chitosan nanoparticles containing Endostar[J].West China Journal of Pharmaceutical Sciences,2011,26(5):414-416. |
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| Authors: | LI Ling WANG Qing-song LIU Chun-hui XU Xiang-yang |
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| Institution: | LI Ling,WANG Qing-song,LIU Chun-hui,XU Xiang-yang* (Jiangsu Simcere Pharmaceutical R&D Co.,Ltd.,Nanjing,Jiangsu,210042,P.R.China) |
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| Abstract: | OBJECTIVE To study the encapsulation efficiency(EE)and the release of recombinant human endostatin(Endostar)loaded in a biodegradable polymer Chitosan.METHODS Chitosan nanoparticles containing Endostar were prepared by high molecular combined methods.The formation conditions and freeze-dried process of nanoparticles were studied.The characterizations including morphology,drug loading,encapsulation efficiency,in vitro release,and SDS-PAGE were investigated.RESULTS The nanoparticles were formed at the mass ra... |
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| Keywords: | Endostar Chitosan Carboxymethylcellulose sodium Nanoparticle |
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