| 林蛙皮提取物对动物实验性胃溃疡的防治作用 |
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| 引用本文： | 施溯筠,周航,杨杰,李元,崔贤淑,李秀国. 林蛙皮提取物对动物实验性胃溃疡的防治作用[J]. 华西药学杂志, 2011, 26(5): 454-457 |
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| 作者姓名： | 施溯筠 周航 杨杰 李元 崔贤淑 李秀国 |
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| 作者单位： | 1. 延边大学药学院,吉林延吉,133000
2. 延边大学基础医学院,吉林延吉,133000 |
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| 基金项目： | 延边大学“211”工程三期建设项目(YB211-2) |
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| 摘 要： | 目的 探讨林蛙皮提取物(RCSE)对实验性胃溃疡的防治作用.方法将动物随机分为模型组、西咪替丁组和3个RCSE组.通过小鼠水浸束缚应激性溃疡实验、大鼠幽门结扎型溃疡实验和醋酸诱发的胃溃疡实验观察溃疡发生的程度,测定血浆和胃组织中谷胱甘肽过氧化物酶( GSH - Px)、超氧化物歧化酶(T-SOD)的活力和丙二醛(MDA...
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| 关 键 词： | 胃溃疡 抗氧化 林蛙皮提取物 小鼠 大鼠 |
Preventive and therapeutic effects of Rana chensinensis skin extracts on experimental gastric ulcers |
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| SHI Su-yun , ZHOU Hang , YANG Jie , LI Yuan , CUI Xian-shu , LI Xiu-guo. Preventive and therapeutic effects of Rana chensinensis skin extracts on experimental gastric ulcers[J]. West China Journal of Pharmaceutical Sciences, 2011, 26(5): 454-457 |
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| Authors: | SHI Su-yun ZHOU Hang YANG Jie LI Yuan CUI Xian-shu LI Xiu-guo |
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| Affiliation: | SHI Su-yun1,ZHOU Hang2,YANG Jie2,LI Yuan2,CUI Xian-shu1,LI Xiu-guo2* (1.College of Pharmacy,Yanbian University,Yanji,Jilin,133000 P.R.China,2.College of Basic Medicine,133000 P.R.China) |
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| Abstract: | OBJECTIVE To investigate the preventive and therapeutic effects of Rana chensinensis skin extracts(RCSE) on three kinds of experimental gastric ulcers.METHODS Animals were randomly divided into model control,cimetidine and three RCSE groups.The GSH-Px and T-SOD activity,MDA content in plasma and gastric tissue were detected in three kinds of gastric ulcer models,water immersion stressed mice,pylorus ligated rats and acetic acid induced rats.RESULTS Compared with the model control group,three doses of RCSE s... |
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| Keywords: | Gastric ulcer Ant-oxidation Rana chensinensis skin extracts Mice Rat |
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